Hidehiro Mizusawa Selected Research

Alzheimer Disease (Alzheimer's Disease)

2/2022	Soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for differential diagnosis of mild cognitive impairment.
1/2019	Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice.
1/2017	Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.
1/2015	Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme.
10/2010	Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.
1/2010	Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress.
11/2009	Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.
9/2008	Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.
11/2006	Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse.
10/2003	Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan.

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Hidehiro Mizusawa Research Topics

Disease

21	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 10/2019 - 04/2003
18	Cerebellar Ataxia (Dysmetria) 11/2017 - 05/2002
15	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2022 - 11/2008
12	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2019 - 05/2002
10	Alzheimer Disease (Alzheimer's Disease) 02/2022 - 10/2003
8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2022 - 04/2002
8	Parkinson Disease (Parkinson's Disease) 04/2015 - 05/2002
7	Multiple System Atrophy 01/2016 - 05/2002
7	Stroke (Strokes) 01/2015 - 06/2003
6	Sporadic Creutzfeldt-Jakob Disease 01/2019 - 02/2009
6	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 03/2018 - 11/2007
6	Ataxia (Dyssynergia) 01/2018 - 05/2013
6	Multiple Sclerosis 01/2018 - 10/2004
6	Neoplasms (Cancer) 01/2016 - 02/2008
5	Dementia (Dementias) 02/2017 - 05/2002
4	Cognitive Dysfunction 02/2022 - 11/2006
4	Neurologic Manifestations (Neurological Manifestations) 12/2018 - 05/2002
4	Infections 01/2018 - 11/2010
4	Atrophy 01/2016 - 11/2004
4	Nervous System Diseases (Neurological Disorders) 01/2015 - 10/2004
4	Ischemia 06/2012 - 01/2006
3	Myoclonus (Nocturnal Myoclonus) 12/2018 - 08/2008
3	Motor Neuron Disease (Primary Lateral Sclerosis) 04/2017 - 09/2010
3	Progressive Multifocal Leukoencephalopathy 01/2016 - 11/2011
3	Neuromyelitis Optica (Devic's Disease) 01/2016 - 06/2013
2	Acquired CJD 01/2022 - 05/2014
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 07/2018 - 12/2013
2	Sarcoma (Soft Tissue Sarcoma) 07/2018 - 12/2013
2	Dermatomyositis (Dermatopolymyositis) 07/2015 - 03/2012
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2015 - 02/2013
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2015 - 02/2007
2	Stiff-Person Syndrome (Stiff Man Syndrome) 01/2015 - 05/2013
2	Poisoning 01/2014 - 03/2009
2	Ischemic Stroke 02/2013 - 10/2006
2	Myasthenia Gravis 01/2013 - 05/2003
2	HIV Infections (HIV Infection) 10/2012 - 11/2011
2	Leukocytosis (Pleocytosis) 11/2011 - 12/2008
2	Brain Ischemia (Cerebral Ischemia) 09/2011 - 11/2003
2	Liver Diseases (Liver Disease) 02/2011 - 01/2011
2	Diarrhea 02/2010 - 05/2003
2	Nonaka type Distal myopathy 03/2008 - 10/2002
2	Infarction (Infarctions) 10/2007 - 01/2006
2	Hepatitis C 09/2007 - 06/2003
2	Pick Disease of the Brain (Pick's Disease) 03/2006 - 12/2005

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 02/2022 - 05/2002
13	Prion ProteinsIBA 01/2019 - 10/2003
12	polyglutamineIBA 01/2017 - 08/2006
11	Codon (Codons)IBA 01/2022 - 10/2003
8	Small Interfering RNA (siRNA)IBA 02/2014 - 06/2003
7	Calcium Channels (Calcium Channel)IBA 10/2019 - 04/2003
7	PrionsIBA 01/2019 - 08/2007
6	Biomarkers (Surrogate Marker)IBA 02/2022 - 01/2013
6	AutoantibodiesIBA 01/2016 - 05/2002
6	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2016 - 04/2003
6	voltage-dependent calcium channel (P-Q type)IBA 09/2015 - 08/2008
5	Methionine (L-Methionine)FDA Link 01/2022 - 11/2007
5	NucleotidesIBA 11/2017 - 08/2005
4	Amyloid (Amyloid Fibrils)IBA 02/2022 - 01/2017
4	AntibodiesIBA 04/2016 - 09/2002
4	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2015 - 11/2006
4	Messenger RNA (mRNA)IBA 02/2014 - 03/2008
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2011
3	Valine (L-Valine)FDA Link 01/2018 - 09/2014
3	Protein Isoforms (Isoforms)IBA 01/2017 - 03/2006
3	Dopamine (Intropin)FDA LinkGeneric 10/2016 - 01/2010
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2014 - 05/2003
3	UbiquitinIBA 12/2013 - 10/2005
3	alpha-SynucleinIBA 03/2008 - 05/2002
2	DNA-Binding Proteins (DNA Binding Protein)IBA 07/2018 - 10/2010
2	LithiumIBA 01/2018 - 05/2007
2	RNA (Ribonucleic Acid)IBA 04/2017 - 12/2013
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2017 - 05/2003
2	Glutens (Glutelin)IBA 04/2016 - 10/2014
2	Mefloquine (Lariam)FDA LinkGeneric 01/2016 - 01/2013
2	GliadinIBA 01/2016 - 10/2014
2	Phenytoin (Dilantin)FDA LinkGeneric 01/2016 - 10/2014
2	Intravenous Immunoglobulins (IVIG)FDA Link 07/2015 - 04/2010
2	alpha-tocopherol transfer proteinIBA 01/2015 - 11/2009
2	EpitopesIBA 01/2015 - 10/2005
2	Prednisolone (Predate)FDA LinkGeneric 03/2014 - 02/2014
2	PENTAIBA 12/2013 - 11/2009
2	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 12/2008
2	Galectin 1 (LGALS1)IBA 09/2011 - 10/2007
2	SteroidsIBA 04/2010 - 07/2009
2	CalciumIBA 01/2010 - 08/2008
2	Amyloid beta-PeptidesIBA 11/2009 - 09/2008
2	Vitamin E FDA LinkGeneric 11/2009 - 11/2006
2	Uridine Diphosphate (UDP)IBA 03/2008 - 10/2002
2	AcetylglucosamineIBA 03/2008 - 10/2002
2	Racemases and Epimerases (Epimerases and Racemases)IBA 03/2008 - 10/2002
2	N-acylmannosamine kinaseIBA 03/2008 - 10/2002
2	Ataxin-1IBA 01/2008 - 05/2007

Therapy/Procedure

21	Therapeutics 01/2022 - 05/2003
7	Transplantation 10/2013 - 11/2003
3	Blood Transfusion (Blood Transfusions) 11/2009 - 02/2009
3	Operative Surgical Procedures 11/2009 - 02/2009
3	Lasers (Laser) 03/2006 - 12/2005
2	Thymectomy 12/2018 - 05/2003
2	Immunotherapy 01/2016 - 04/2013
2	Aftercare (After-Treatment) 03/2014 - 02/2014